Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The top-earning woman in the music business has been cashing in on a massive world tour, a constant stream of hit singles and a string of endorsements with a slew of major companies, while occasionally throwing thinly veiled barbs at her chief rival.
Trends and targets in antiviral phototherapy
In truth, slower growth of about 8 per cent could be better for China and for the world. More environmentally sustainable and equitable outcomes would ease popular concerns and higher consumption would ease tensions over global trade.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The relatively stable global outlook must continue if 2014 is to be the kind of economic year Americans have been hoping for throughout the recovery.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
History will look back on 2012 as the year when China anointed its "fifth generation" of leaders and shifted to a slower growth trajectory, writes Yukon Huang. This transition will take place against a backdrop of daunting internal challenges — increasing social unrest, widening income disparities and both ecological and man-made disasters — and of escalating external tensions, stemming from America's "pivot" to Asia and simmering regional worries about China's economic rise.
ACE2 as a potential therapeutic target for pandemic COVID-19
Chinese Cultural Relics is a new journal that translates Chinese-language articles, originally published in the journal Wenwu, into English. The discovery of the 1,700-year-old cemetery was included in its inaugural issue.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Three Billboards Outside Ebbing, Missouri
这封情书是寄给一个叫做Clark C Moore，但是现在已经改名为Muhammad Siddeeq先生的，由于这次改名，让这封信找到真正的收件人变得尤为困难。
Warren Buffett reclaimed the No. 2 spot on the list for the first time since 2014, with a net worth of $75.6 billion, up from $60.8 billion in 2016.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Then there were these cautionary tales, where a candidate
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Ariel Foxman In Style
与此同时，法国拉罗谢尔高等商学院(La Rochelle Business School)的排名却下滑12个位置，排在第60位，去年该学校是排名上升最快的学校之一。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Swyft now makes half of its money from ad campaigns like the one for Gwen Stefani. Swyft’s revenue has increased between 50% and 100% each month, Wray says. The other half comes from selling stickers—typically licensed from sports teams and entertainment brands like Shrek.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
'Gangnam Style' beat 'Call Me Maybe' as the most trending pop song and 'Skyfall' topped 'Prometheus' as the most enquired about film.
Antiviral drug discovery: broad-spectrum drugs from nature
Pop superstar Gaga also took home the award for best actress in a limited television series or movie for her role as the villainous Countess in American Horror Story: Hotel. The Born This Way singer made an emotional speech as she was awarded a Golden Globe for her role in the HBO hit.
Influenza neuraminidase: A druggable target for natural products
As he scanned the Internet for knowledge, D'Aloisio decided that what he really needed was a better way to determine, at a glance, what was worth reading. He envisioned a summarization tool that used language theory to give a meaningful synopsis in fewer than 400 characters.
TOGETHERNESS (HBO, Jan. 11) HBO’s Sunday night comedy block already covers early-20-something New York women (“Girls,” beginning its fourth season the same night) and late-20-something San Francisco gay men (“Looking,” beginning its second). Now it adds 30-something Los Angeles straight people in this sometimes bleakly comic half-hour from Jay and Mark Duplass, the brothers behind quirky films like “The Puffy Chair” and “Baghead.” Mark Duplass and Melanie Lynskey play a married couple sharing a house with his best friend (Steve Zissis) and her sister (Amanda Peet).
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
Common industries for college startups include catering, agriculture, IT, transportation, education and culture. 13.8% of the entrepreneurs were interested in hospitality and catering, while 13.7% chose agriculture, the report said.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Episodic memory is also known as long-term memory, and the researchers approached the study of exercise in a different manner than previous studies. Other studies examined the impact of aerobic exercise conducted over many months, but this study simply asked participants to lift weights a single time. During the test, half of the participants were asked to use a weight machine before recalling a series of images they were shown at the start of the test. The other half of the participants were also asked to recall the images but without having engaged in any strenuous activity before the recall session. In demonstrating the memory improvement for the participants who engaged in just a single session of weight lifting, the researchers were able to show that improving one's memory through exercise didn't take hours of dedication in the gym. The next time you have the opportunity to lift weights or someone tries to convince you to join the gym you might just want to take him or her up on the offer.
Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The Datafolha poll was based on interviews with 693 fans at the Mineirao stadium in Belo Horizonte and had a statistical margin of error of 4 percentage points.
Stand: Whole Foods CEO John Mackey called for 'Conscious Capitalism'
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
The clue may be in the price: the H-share index is cheap. On seven times 2016 earnings, it trades at a lower multiple than Spain (with 22 per cent unemployment), Brazil (dependent upon commodities and thus China), and both Turkey and Egypt, affected by Middle Eastern turmoil.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Change is also under way at Bain & Company, which announced in November that Manny Maceda will become its global leader in March, the first of Asian heritage, and taking the reins of the Boston-based consultancy from Bob Bechek. Experts say Mr Maceda could be instrumental in helping the firm carve out new areas of expertise and edge away from its reputation as a generalist provider.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Russia's economy is the 10th largest in the world, producing little of value beyond hydrocarbons. Corruption and rent-seeking extract an enormous economic toll. It remains burdened with Soviet era infrastructure, and its ability to meet the educational and medical needs of its population is rapidly declining.
The kitchen addition, about 40 feet long, was designed to be in keeping with the original house, with intricate ceiling woodwork and several colored-glass panels by Century Studios, a Minneapolis company that secured its glass from the Chicago manufacturer used by Frank Lloyd Wright. Stainless-steel appliances include a five-foot-wide range and a Sub-Zero refrigerator. The dining area opens to a back patio through 10-foot-tall glass doors.
以丹麦为例，如今，88%的丹麦人口都是白人——这样的多数地位很难动摇。但在1980年，也就是上一代人的时候，丹麦有97%的人口是白人。反移民的丹麦人民党(Danish People’s Party)现在是丹麦议会中的第二大党。在德国，从2011年到2015年间，非本土出生人口激增了大约75%，反移民的民粹政党德国另类选择党(Alternative for Germany)如今获得了破纪录的支持率。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
政府部门的数据显示，无论在销售额和销售量上看，今年上半年香港房地产销售较去年同期下降了近40%。香港差饷物业估价署(Rating and Valuation Department)本月发布的一项指数表明，商业地产受到的冲击尤为严重，今年5月价格较去年同期下降了5.7%。
The overall 2018 ranking encompasses more schools than ever before – 1,250 universities located across 74 countries. This is an increase from the 1,000 schools in 65 countries included in last year's edition.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Everyone loves cookies, but buying a smart cookie oven to make them seems like a bit much. The CHIP cookie oven promises to have freshly baked cookies in just 10 minutes, but regardless of the time, it just seems easier to make a much larger batch using the regular old oven.
A New Year greeting to cheer you from your daughters.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Surveys indicate that a majority of women suffer or have suffered gender prejudice when looking for a job, because employers do not want to grant maternity leave. To avoid possible gender discrimination from employers as a result of their entitlement to maternity leave and increase their employment competitiveness, some female job seekers have reportedly chosen to get married and have their children before graduating from universities.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
其他机构有宝钢集团(Shanghai Baosteel Group)旗下为钢材交易商提供融资的欧冶云商(Ouyeel)、中国第六大银行招商银行(China Merchants Bank)旗下专注财富管理领域的小企业e家(Small Entrepreneur)等。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
3. Tablets meet viruses.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
At the center of the speculation is BlackBerry’s healthy intellectual property portfolio, 44,000 patents and still growing. Last October, for example, the company won at least 27 new ones—covering everything from conference-calling interfaces to touch screens to security features for wearable technologies such as smart watches, eyeglasses and fitness bands. Security continues to be BlackBerry’s biggest selling point with businesses. Just ask the Sony movie studio division, which “resorted” to outdated BlackBerrys to restart communications after its security breach last Thanksgiving.
At its own auction the following evening, Sotheby’s achieved a far more respectable total of 22.6 million with fees, although it was just above the low estimate of 21.8 million based on hammer prices. Of the 44 lots offered, 15 did not sell, or 34 percent.
The University of St Gallen’s domination of the Financial Times’ ranking of masters in management courses continues for another year.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Businesses can benefit in other ways too. Craig Rollason, business analysis manager at National Grid, says he has improved his coaching skills by mentoring a Teach Firster.
"This is something we believe is really important for the future of our country,"Facebook (FB, Fortune 500) CEO Mark Zuckerberg said in August.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
In a closely fought debate about the six shortlisted titles, one judge described Mr Ford’s book as “a hard-headed and all-encompassing” analysis of the problem. Lionel Barber, FT editor and chair of the judging panel, called The Rise of the Robots “a tightly written and deeply researched addition to the public policy debate”.
No.4: The 1st Useful Mechanical Pet
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Creditors have officially approved the MGM restructuring plan that will put Spyglass Entertainment in charge of the studio, getting it moving once again. MGM will no longer be a distributor, but a working studio, which now puts James Bond 23 on the auction block and closer to an actual start date. Here is the official announcement from MGM:
These larger screen sizes will put additional strain on iOS 7 and developers who will need to figure out how to adapt their apps to even more configurations. These additional formats will provide some exciting opportunities for applications as well, and we can anticipate that iOS 8 will contain many features designed to accommodate multi-screen design.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Apple Inc.'s Chief Executive Officer Steve Jobs is shown in this combination photo of file photographs dating (top row L to R) July 2000, November 2003, September 2005, (bottom L to R) September 2006, January 2007 and September 2008. Jobs will take a medical leave of absence until the end of June because his health problems are "more complex" than he had thought, shocking investors and sending the company's shares down as much as 10 percent on January 14, 2009.
3. JetBlue. Brand love: 40% / Rank 218
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The consumer price index rose by 1.8 per cent year-on-year in January, from 1.6 per cent in December 2015. However, CPI continues to trail Beijing’s target of “around 3 per cent“.
Hong Kong has topped the list for the past seven years -- since its first appearance in the survey.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
52% of the world lived in extreme poverty in 1981. This number dropped down by 21% in 2010, as 721 million fewer people no longer live in absolute poverty.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Welcome as they were, surging sales weren't the biggest news of the year. Detroit celebrated when General Motors (GM, Fortune 500) made Mary Barra the auto industry's first female CEO, then held its breath while Ford (F, Fortune 500) CEO Alan Mulally dithered over a move to Seattle and Microsoft. The old Big Three, complaining about straining available production capacity, made plans to expand and hire. Tesla(TSLA) fired up electric car sales and refused to play by industry's rules, while Google(GOOG, Fortune 500) pioneered a car that drives itself.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Set over one summer, the film follows precocious 6-year-old Moonee as she courts mischief and adventure with her ragtag playmates and bonds with her rebellious but caring mother, all while living in the shadows of Disney World.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
At present, 15 Chinese cities allow a 72-hour visa-free entry for nationals of certain countries. Shanghai, Jiangsu and Zhejiang offer 144-hour visa-free stays for international transit passengers from certain countries.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
'With women, he has this sort of patronising carnal attitude with them which is absolutely accurate to the Bond of the books. But then by creating very strong women he is given quite a run for his money and his attitudes are challenged.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Brian Kendrella, president of New York-based Stack's Bowers Galleries, says the auction drew half a dozen bidders from six countries. The winning bidder Thursday was an individual collector from Asia who asked to remain anonymous.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Meanwhile, 78 percent of the civil service jobs offered this year are posts at county or district levels, as the central government seeks to steer more college graduates to jobs at city and county levels, he said.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
德系三巨头：由于奔驰的几款低价产品不可避免地会损害它“要么最好，要么什么都不是”(the best or nothing)的商誉，该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外，起价30,795美元的奥迪A3，很可能会使奥迪的销量较2014年增长15%，新款Q7也将进一步提高奥迪的利润。
6. Google Adwords Keyword Planner
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
It plans to help at least 130,000 rural people cast off poverty and relocate 163,000 residents in 2017.
Length-scale dependence of protein hydration-shell density
China's box office sales hit a record high in 2015, by pulling in 44 billion yuan, or some 6.8 billion US dollars, with domestic films accounting for a large chunk of that growth.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Among the amenities spread through its three terminals are two 24-hour movie theaters screening the latest blockbusters for free, a rooftop swimming pool and a butterfly garden.
About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
斯坦福大学的Zhenan Baohas 研发出了一种具备超弹性、超耐性和超敏感的材料，能够作为未来发展人工皮肤的基础。以前，人们也研究过生化皮肤，但是Baohas的材料比以前研发出来的更具敏感性。它带有有机转换物质和一层弹性材料，保证它在不被破坏情况下的延展性。另外，这种材料带有一系列的太阳能电池元件，可以自动充电。
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During the same period, Braziland Russia slashed their holdings to USD 261.7 billion and USD 108.9 billion,respectively.